He seguido buscando info de configuraciones, y me sigue yendo fluído, y ahora se me ve bastante mejor (probado a 4, en un par de pantallas distintas). Pongo la información:
DOLPHIN SETTINGS
First, go to Options->Wiimote Settings.
Make sure all wiimotes are set to NONE. This causes desyncs.
Now go to Options->Configure.
Under General, Enable Dual Core and Idle Skipping should be the only things checked.
Under Interface, Use Panic Handlers should be the only thing checked.
Under Audio, ensure that the Emulator Engine is using DSP HLE and the backend is XAudio2. Everything else should be unchecked.
Under Gamecube, set both memory card slots to nothing. This is if you want to play melee netplay just incase. Ensure that you have a Standard Controller under port 1 and the rest are nothing (unless somebody else is plugged into your computer).
Under Wii Make sure that Insert SD Card is UNCHECKED. This causes desyncs.
Now go to Options->Graphics Settings.
Under General, your backend should either be Direct3D or OpenGL. The best one will differ depending on your computer. OpenGL will be better on most NVIDIA GPU's when you enable Vertex Streaming Hack under the Hacks tab. Test both and see which runs better.
Render to Main Window should be the only thing checked.
Under Enhancements, Internal Resolution should be set to Auto (window size) for maximum performance. My GPU is capable of running at 4x Native with no frame loss and it proves to be a much much better image resolution. You may increase this until you notice your frames drop.Anti Aliasing and Anisotropic Filtering should be set to none for max performance, my GPU cannot handle AA but it can handle AF at 16x with no frame loss. Everything should be unchecked.
Under Hacks, Skip EFB Access from CPU and Ignore Format Changes should both be checked. EFB Copies should be set to Texture. Texture Cache should be set to Fast. External Frame Buffer should be Disabled. Cache Display Lists, OpenMP Texture Decoder, and Fast Depth Calculation should be checked while OpenCL Texture Decoder and Disable Destination Alpha should be unchecked.
Under Advanced, everything should be unchecked.
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Añado también los requisitos que dicen para que el juego vaya bien:
Minimum Requirements (2 player, 480p/60 FPS):
Processor: Intel Core 2 Duo E8600 or AMD Phenom X2 555
Memory: 4 GB DDR3
Graphics Card: nVidia GeForce 8800 GT or AMD Radeon HD 4770
Operating System: Windows Vista 32-bit or OS X 10.6 "Snow Leopard" 32-bit
Recommended Specifications (4 player, 720p/60 FPS):
Processor: Intel Core i5-2500K or AMD Phenom X4 955
Memory: 4 GB DDR3
Graphics Card: nVidia GeForce GTX 560 or AMD Radeon HD 7850
Operating System: Windows 7 64-bit or OS X 10.9 "Mavericks" 64-bit